Learn the truth about industrial hemp extract cannabidiol CBD _ Treatm…
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작성자 Selby 댓글 0건 조회 82회 작성일 23-02-22 11:12본문
Original Title: The Truth About Cannabidiol CBD, an Industrial Hemp Extract Cannabidiol Cannabidiol (CBD) is a pure natural ingredient extracted from cannabis plants. Cannabis as a medicine has a long history, which can be traced back to thousands of years ago. Today, the therapeutic properties of CBD are being tested and confirmed by scientists and doctors around the world. CBD is a safe, non-addictive substance, one of more than a hundred "phytocannabinoids.". These "phytocannabinoids" are specific to cannabis and give it a powerful therapeutic effect. By digging deeper into our physiological functions, it is found that hemp CBD oil can be used in medicine, cosmetics, skin care products and health care products. Medical-grade cannabis CBD, with a content of more than 99%, is the crown jewel of cannabis. Pharmaceutical grade high purity CBD crystals, $100 million per ton. As early as 2003, cannabidiol CBD was patented by the U.S. government as a neuroprotective agent and antioxidant. However, in recent years, low concentration of CBD has appeared in health care products, food and skin care products, and has gradually been recognized by most people. Uses of cannabidiol include, but are not limited to: 1. Treat epilepsy Epidiolex, a drug containing 98% CBD in the United States, was approved by the FDA on June 25, 2018 for the treatment of severe seizures in Lennox-Gastaut syndrome in patients 2 years of age and older. 2. Improve mood 1.resist anxiety Can be used as a dietary supplement for improving mood and resisting anxiety. However, you can rest assured that CBD oil at low concentrations has no stimulating effect at all, nor will it be addictive. People with too much stress, insomnia and anxiety can take it properly. 3. Anti-inflammatory Relieving joint and nerve pain, etc. At present,wiped film distillation, the study of CBD has also found that it has certain effects in anti-rheumatoid arthritis, gastroenteritis, anorexia, brain tumors and other aspects, and also has some help in the prevention of cancer and diabetes. 4. Reduce dependence on alcohol and nicotine It is very helpful to prevent liver cancer and cirrhosis, and is very suitable for people who drink and smoke for a long time. 5. Neonatal hypoxic-ischemic encephalopathy (NHIE) In 2015, GW Pharmaceuticals developed an intravenous injection using CBD, which has been granted OrphanDrug Designation by the US Food and Drug Administration (FDA) for the treatment of neonatal hypoxic-ischemic encephalopathy (NHIE). 6. CBD oil can also be used in skin care products and health care products. The role of CBD oil in the field of skin care can be said to be very versatile, from the basic control of water and oil balance,jacketed glass reactor, to anti-inflammatory sterilization, against acne, to relieve dermatitis, to relieve muscles, promote sleep, all kinds of problems faced by the skin.
Basic information Chinese name: cannabidiol Chinese alias: polyphenol resin CAS No.: 13956 -29-1 Expand the full text English name: Cannabidiol Molecular formula: C21H30O2 Molecular weight: 314. 46200 Structural formula: Physical and chemical properties Appearance and properties: white or off-white to light yellow crystalline powder Density: 1.025 G/cm3 Melting point: 66-67 ° (almost insoluble in water or 10% sodium hydroxide solution, very soluble in ethanol and methanol) Boiling point: 463.9º Cat760mmHg Flash point: 206.3ºC Refractive index: 1.545 Vapor pressure: 3.14 E-09 mmHg at 25 ° C Storage conditions: 2-8 ℃, low temperature, ventilated and dry, stored separately from food raw materials Packing: Use medicinal low-density polyethylene bags as inner packing, polyester/aluminum/polyethylene medicinal composite bags as outer packing, and cartons or cardboard barrels for transport packing Product expiration date: about 2 years Security information RT ECS No.: VH1600000 Dangerous goods mark: F, T Hazard Code: R11 Dangerous goods transport number: UN1230 3 WGKGermany：1 The preparation method At present, there are two methods to prepare cannabidiol in industry: plant extraction and chemical synthesis. At present, the main purification method of cannabidiol is resin adsorption. 1. Plant extraction method Up to now, the raw material of cannabidiol in China comes from industrial hemp with tetrahydrocannabinol content less than three thousandths, and the product properties include crystal, hemp extraction centrifuge ,cbd crystallization equipment, paste and oil. To extract and purify cannabidiol from industrial hemp, there are currently three related patent documents, as shown in Table 1: Table 1. Patent for extraction and purification of cannabidiol In the first patent [19], the extracted raw material part is the flower and leaf of industrial hemp in full bloom, at this time, the content of cannabidiol is relatively high, and at the same time, organic solvents such as petroleum ether, n-hexane or 6 # solvent oil are used to leach the raw material, because the cannabidiol components in the original plant are complex and there are many components with similar polarity, after extraction and refining, the purity of cannabadiol in the final product is not high. Tetrahydrocannabinol, a psychotoxic component, can still be detected, and the safety of the product can not be guaranteed. In the preparation process, toxic organic solvents such as petroleum ether, n-hexane, dichloromethane and the like are used, and the use of the organic solvents is harmful to the environment; and if the solvent residues in the final product cannot be completely removed, the safety of the product is also affected. The second patent [20], based on the process of the first patent, uses ethanol to leach the raw materials and as a chromatographic elution medium, which not only improves the purity of cannabidiol in the finished product, but also removes a certain amount of tetrahydrocannabinol, a psychotoxic component, and improves the safety of the product, and is suitable for industrial production. The third patent [21] is a further improvement of the second patent [19], in which supercritical carbon dioxide extraction is used to obtain a crude extract, which is then dissolved in ethanol, followed by a series of separation and purification operations. The method improves the purity of the cannabidiol, removes the psychotoxic component tetrahydrocannabinol in the finished product, ensures the safety of the product, reduces the influence on the environment, operators and residual solvent of the product by using ethanol and water as reagents, and simultaneously reduces the environmental pollution caused in the column chromatography process and the harm to personnel. But supercritical extraction equipment is expensive. 2. Chemical synthesis method At present, cannabidiol products are mainly derived from chemical synthesis methods, mainly international patents. The comparison of different methods is as follows: 1) Patent WO2006053766A1 (a purification method of cis-tetrahydrocannabinol and trans-tetrahydrocannabinol) uses zinc chloride catalysis for the synthesis of the target product. The purity was only 97.1% and the yield was only 22% by column crystallization purification process. Because the largest impurity in the reaction process is dimer, which reaches more than 20%, and the impurity needs more than three times of crystallization to reduce to less than 0.1% (to meet the requirements of API indicators).
The total yield was only 13% when the qualified bulk drug was obtained, and the process cost was high. 2) Patent US20090036523A1 (a prodrug of cannabidiol and a method for using the components of the prodrug) uses olivetol as a starting material and p-toluenesulfonic acid as a catalyst to obtain the target product in one step, but the reaction system is complex, has many isomers and dimers, is troublesome in post-treatment, requires column chromatography purification, and has low yield. Only 24%. 3) Patent US20100298579A1 (a method for preparing synthetic cannabidiol) uses 2,4-dihydroxy-6-pentylbenzoic acid methyl ester as the starting material, and uses boron trifluoride diethyl etherate as the catalyst to prepare the coupled methyl ester intermediate (I). The purity of the reaction is slightly higher than that of the one-step method, and the isomers and dimers are obviously less than those of the one-step method. However, the purity of the methyl ester intermediate after coupling is still only about 75% after acid-base treatment, and the melting point of the compound may be low, so it can not be crystallized. Methyl ester intermediate (I) can not be recrystallized and purified by conventional methods, so it can not meet the requirements of chemical purity and impurity indicators of key intermediates as APIs. Major suppliers According to the online inquiry and summary, the domestic manufacturers of Procannabidiol include Yunnan Mabaosu Biotechnology Co., Ltd. and Shanghai Special Pharmaceutical Technology Co.,rotary vacuum evaporator, Ltd. Among them, Hansu Biology uses alcohol-soluble fluid crystallization technology to extract and separate cannabidiol CBD (known as DM CBD in China) from industrial hemp. The CBD cannabinoid extraction process patent has been authorized by the United States, which has won the international patent for cannabinoid medicinal extraction for China. Return to Sohu to see more Responsible Editor:. toptiontech.com
Basic information Chinese name: cannabidiol Chinese alias: polyphenol resin CAS No.: 13956 -29-1 Expand the full text English name: Cannabidiol Molecular formula: C21H30O2 Molecular weight: 314. 46200 Structural formula: Physical and chemical properties Appearance and properties: white or off-white to light yellow crystalline powder Density: 1.025 G/cm3 Melting point: 66-67 ° (almost insoluble in water or 10% sodium hydroxide solution, very soluble in ethanol and methanol) Boiling point: 463.9º Cat760mmHg Flash point: 206.3ºC Refractive index: 1.545 Vapor pressure: 3.14 E-09 mmHg at 25 ° C Storage conditions: 2-8 ℃, low temperature, ventilated and dry, stored separately from food raw materials Packing: Use medicinal low-density polyethylene bags as inner packing, polyester/aluminum/polyethylene medicinal composite bags as outer packing, and cartons or cardboard barrels for transport packing Product expiration date: about 2 years Security information RT ECS No.: VH1600000 Dangerous goods mark: F, T Hazard Code: R11 Dangerous goods transport number: UN1230 3 WGKGermany：1 The preparation method At present, there are two methods to prepare cannabidiol in industry: plant extraction and chemical synthesis. At present, the main purification method of cannabidiol is resin adsorption. 1. Plant extraction method Up to now, the raw material of cannabidiol in China comes from industrial hemp with tetrahydrocannabinol content less than three thousandths, and the product properties include crystal, hemp extraction centrifuge ,cbd crystallization equipment, paste and oil. To extract and purify cannabidiol from industrial hemp, there are currently three related patent documents, as shown in Table 1: Table 1. Patent for extraction and purification of cannabidiol In the first patent [19], the extracted raw material part is the flower and leaf of industrial hemp in full bloom, at this time, the content of cannabidiol is relatively high, and at the same time, organic solvents such as petroleum ether, n-hexane or 6 # solvent oil are used to leach the raw material, because the cannabidiol components in the original plant are complex and there are many components with similar polarity, after extraction and refining, the purity of cannabadiol in the final product is not high. Tetrahydrocannabinol, a psychotoxic component, can still be detected, and the safety of the product can not be guaranteed. In the preparation process, toxic organic solvents such as petroleum ether, n-hexane, dichloromethane and the like are used, and the use of the organic solvents is harmful to the environment; and if the solvent residues in the final product cannot be completely removed, the safety of the product is also affected. The second patent [20], based on the process of the first patent, uses ethanol to leach the raw materials and as a chromatographic elution medium, which not only improves the purity of cannabidiol in the finished product, but also removes a certain amount of tetrahydrocannabinol, a psychotoxic component, and improves the safety of the product, and is suitable for industrial production. The third patent [21] is a further improvement of the second patent [19], in which supercritical carbon dioxide extraction is used to obtain a crude extract, which is then dissolved in ethanol, followed by a series of separation and purification operations. The method improves the purity of the cannabidiol, removes the psychotoxic component tetrahydrocannabinol in the finished product, ensures the safety of the product, reduces the influence on the environment, operators and residual solvent of the product by using ethanol and water as reagents, and simultaneously reduces the environmental pollution caused in the column chromatography process and the harm to personnel. But supercritical extraction equipment is expensive. 2. Chemical synthesis method At present, cannabidiol products are mainly derived from chemical synthesis methods, mainly international patents. The comparison of different methods is as follows: 1) Patent WO2006053766A1 (a purification method of cis-tetrahydrocannabinol and trans-tetrahydrocannabinol) uses zinc chloride catalysis for the synthesis of the target product. The purity was only 97.1% and the yield was only 22% by column crystallization purification process. Because the largest impurity in the reaction process is dimer, which reaches more than 20%, and the impurity needs more than three times of crystallization to reduce to less than 0.1% (to meet the requirements of API indicators).
The total yield was only 13% when the qualified bulk drug was obtained, and the process cost was high. 2) Patent US20090036523A1 (a prodrug of cannabidiol and a method for using the components of the prodrug) uses olivetol as a starting material and p-toluenesulfonic acid as a catalyst to obtain the target product in one step, but the reaction system is complex, has many isomers and dimers, is troublesome in post-treatment, requires column chromatography purification, and has low yield. Only 24%. 3) Patent US20100298579A1 (a method for preparing synthetic cannabidiol) uses 2,4-dihydroxy-6-pentylbenzoic acid methyl ester as the starting material, and uses boron trifluoride diethyl etherate as the catalyst to prepare the coupled methyl ester intermediate (I). The purity of the reaction is slightly higher than that of the one-step method, and the isomers and dimers are obviously less than those of the one-step method. However, the purity of the methyl ester intermediate after coupling is still only about 75% after acid-base treatment, and the melting point of the compound may be low, so it can not be crystallized. Methyl ester intermediate (I) can not be recrystallized and purified by conventional methods, so it can not meet the requirements of chemical purity and impurity indicators of key intermediates as APIs. Major suppliers According to the online inquiry and summary, the domestic manufacturers of Procannabidiol include Yunnan Mabaosu Biotechnology Co., Ltd. and Shanghai Special Pharmaceutical Technology Co.,rotary vacuum evaporator, Ltd. Among them, Hansu Biology uses alcohol-soluble fluid crystallization technology to extract and separate cannabidiol CBD (known as DM CBD in China) from industrial hemp. The CBD cannabinoid extraction process patent has been authorized by the United States, which has won the international patent for cannabinoid medicinal extraction for China. Return to Sohu to see more Responsible Editor:. toptiontech.com
